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The effects of PDL-Ig on collagen-induced arthritis

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Abstract

Programmed death ligand (PDL) is a new member of the B7 family of costimulatory molecules that specifically interacts with programmed death 1 (PD-1) expressed on activated T cells, B cells, and myeloid cells. Collagen II (CII)-induced arthritis (CIA) is an experimental model of arthritis that has been used to dissect the pathogenesis of human rheumatoid arthritis. In this study, we have investigated the effects of PDL-Ig on CIA. Administration of PDL-Ig significantly ameliorated the disease as assessed by clinical arthritis score and histology in the joints. Expression of proinflammatory cytokines, such as IL-17 and IL-23, in the serum was reduced by PDL-Ig treatment. These results showed a beneficial effect of PDL-Ig on CIA through anti-inflammatory actions and inhibition of cell proliferation in response to CII, suggesting that the PD-1-PDL pathway may be involved in the pathogenesis of CIA, and thus PDL-Ig may be a useful therapy for the improvement of human rheumatoid arthritis.

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Acknowledgments

This study was supported by Wuhan Chenguang Program (No. 20055003059-40).

Conflict of interest statement

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Immunology, Tongji Medical College of Huazhong University of Science and Technology, 430030, Wuhan, China

    Guohua Wang, Jing Yang, Guanxin Shen & Xiongwen Wu

  2. Institute of Biochemistry and Molecular Biology, Hubei University, 430062, Wuhan, China

    Guohua Wang

  3. Department of Microbiology and Immunology, Medical College of Jinan University, 510632, Guangzhou, China

    Ping Hu

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  1. Guohua Wang
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  2. Ping Hu
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Correspondence to Xiongwen Wu.

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Wang, G., Hu, P., Yang, J. et al. The effects of PDL-Ig on collagen-induced arthritis. Rheumatol Int 31, 513–519 (2011). https://doi.org/10.1007/s00296-009-1249-0

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  • DOI: https://doi.org/10.1007/s00296-009-1249-0

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